CO Brain Project

We have been awarded a major grant from the CO Research Trust to investigate the effects of low-level CO on the adult and developing brain. Studies show that the brain is especially vulnerable to CO, which can lead to cognitive and neuropsychiatric problems, and potentially contribute to diseases including stroke and dementia. The vulnerability to CO is not set but rather changes with age; the embryo is particularly at risk with low-level CO linked to birth defects. Yet current studies have focused on the impact of exposure to acute, high levels, and the mechanism by which low-level CO causes health issues in adults and embryos over time is not known. The aim of this project is to address this question, and determine the effects of low-level CO on the brain, looking at the whole scale from cells and tissues, to organ/organism function and structure.

Media Coverage

BBC news / BBC Radio Sheffield interview (from 1:49:20) / Sheffield Star / Yorkshire Bylines

Team

Research team: Dr Mari Herigstad, Professor Marysia Placzek, Dr Chris Morris, Mrs Isabella Myers, Dr Liam Ridge & Dr Prachi Stafford.

Funded by